Effect of metformin and rosiglitazone combination therapy in patients with type 2 diabetes mellitus: a randomized controlled trial

V Fonseca, J Rosenstock, R Patwardhan, A Salzman - Jama, 2000 - jamanetwork.com
ContextMost antidiabetic agents target only 1 of several underlying causes of diabetes. The
complementary actions of the antidiabetic agents metformin hydrochloride and rosiglitazone
maleate may maintain optimal glycemic control in patients with type 2 diabetes; therefore,
their combined use may be indicated for patients whose diabetes is poorly controlled by
metformin alone. ObjectiveTo evaluate the efficacy of metformin-rosiglitazone therapy in
patients whose type 2 diabetes is inadequately controlled with metformin alone …
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