Background The role of neoadjuvant chemotherapy (NAC) for the management of upper
tract urothelial carcinoma (UTUC) remains controversial. The aim of present study was to
evaluate the contemporary role of NAC for patients with locally advanced UTUC through
systematic review and meta-analysis of the literature. Methods Systematic literature
searches were conducted in PubMed/Medline and Embase for all studies that examined the
role of chemotherapy for UTUC. We performed this study according to the Preferred …

Background The outcome of neoadjuvant chemotherapy (NAC) has been established in
bladder cancer but remains controversial in upper tract urothelial carcinoma (UTUC). In this
work, we explored the therapeutic effect of NAC in patients with locally advanced UTUC.
Methods We conducted a literature search on articles published from 1995 up to April 2020
in PubMed/Medline, the Cochrane Library, Embase, Google Scholar. A total of 19 eligible
studies with 6,283 patients were identified, from which the overall survival (OS), cancer …