Effect of oral methylprednisolone on decline in kidney function or kidney failure in patients with IgA nephropathy: the TESTING randomized clinical trial
Importance The effect of glucocorticoids on major kidney outcomes and adverse events in
IgA nephropathy has been uncertain. Objective To evaluate the efficacy and adverse effects
of methylprednisolone in patients with IgA nephropathy at high risk of kidney function
decline. Design, Setting, and Participants An international, multicenter, double-blind,
randomized clinical trial that enrolled 503 participants with IgA nephropathy, proteinuria
greater than or equal to 1 g per day, and estimated glomerular filtration rate (eGFR) of 20 to …
IgA nephropathy has been uncertain. Objective To evaluate the efficacy and adverse effects
of methylprednisolone in patients with IgA nephropathy at high risk of kidney function
decline. Design, Setting, and Participants An international, multicenter, double-blind,
randomized clinical trial that enrolled 503 participants with IgA nephropathy, proteinuria
greater than or equal to 1 g per day, and estimated glomerular filtration rate (eGFR) of 20 to …
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