Importance Weight loss improves cardiometabolic risk factors in people with overweight or
obesity. Intensive lifestyle intervention and pharmacotherapy are the most effective
noninvasive weight loss approaches. Objective To compare the effects of once-weekly
subcutaneous semaglutide, 2.4 mg vs placebo for weight management as an adjunct to
intensive behavioral therapy with initial low-calorie diet in adults with overweight or obesity.
Design, Setting, and Participants Randomized, double-blind, parallel-group, 68-week …