The Varicose vein disease (VVD) is characterized by the enlargement and outward bulging of the veins in the legs. The majority of persons with varicose veins hardly ever see meaningful relief from standard medical treatment. The comprehensive approach of complementary and alternative medicine (CAM) can be used jointly or separately to prevent, minimize, and treat the condition known as enhanced valve competence. Yoga, Ayurveda, Siddha, Homeopathy, and Naturopathy are just a few of the many alternative therapies available through CAM that are affordable. Numerous experimental findings revealed that the alternative therapy works by modifying the hs-CRP protein, enhancing apoptosis, and lowering homocysteine concentration to alleviate the symptoms of varicose vein problems and associated issues.