The study with title effectiveness of scientific project-based student worksheet in improving students’ cognitive, Affective And Psychomotor Aspects, uses a study design experiment are modified as needed. The scientific project worksheets are based on three more specific models: inquiry, Problem-Based Learning (PBL), and Project-Based Learning (PjBL); each was respectively assigned to physiology, animal ecology and biotechnology subjects. The study involved 60 students of class of 2013-2014, consisting of 30 students of controlled group and 30 students of experimental group. The results show that there are significant differences in terms of cognitive, affective and psychomotor aspects of the groups. Hence, it can be concluded that scientific project-based student worksheets are considered effective in improving students’ cognitive, affective and psychomotor aspects via providing them real scientific processes, such as process-oriented investigations of problems, which eventually lead to improvements in terms of the ability to think critically, the development of scientific attitudes, and the ability to build synergistic relationship among involved students in solving problems.