The present study aimed to investigate the protective role of Salvia Miltiorrhiza against Trichloroacetic acid (TCA) induced liver and kidney toxicity in rats. Twenty eight adults Wister albino male rats were divided into 4 equal groups. Group 1 served as control, while group 2 received SM extracts at 200 mg/kg body weight; group 3 was treated with 50 mg/kg/day TCA by gavage daily. Group 4 received the extract at 200 mg/kg body weight and 50 mg/kg/day TCA for two months. A significant increase was observed in liver function, kidney function and MDA (malondialdehyde) levels among the TCA administered animals compared to normal control. Daily oral administration of SM normalized most biochemical changes observed among the TCA treated animals. Histopathologically, higher amount of mononuclear cells infiltration, necrotic cells and few fibroblasts were observed in liver and kidney of TCA treated group. The administration of Salvia Miltiorrhiza extract regulates and decreases liver and kidney damage.