Effects of a protein preload on gastric emptying, glycemia, and gut hormones after a carbohydrate meal in diet-controlled type 2 diabetes
J Ma, JE Stevens, K Cukier, AF Maddox… - Diabetes …, 2009 - Am Diabetes Assoc
Diabetes care, 2009•Am Diabetes Assoc
OBJECTIVE We evaluated whether a whey preload could slow gastric emptying, stimulate
incretin hormones, and attenuate postprandial glycemia in type 2 diabetes. RESEARCH
DESIGN AND METHODS Eight type 2 diabetic patients ingested 350 ml beef soup 30 min
before a potato meal; 55 g whey was added to either the soup (whey preload) or potato
(whey in meal) or no whey was given. RESULTS Gastric emptying was slowest after the
whey preload (P< 0.0005). The incremental area under the blood glucose curve was less …
incretin hormones, and attenuate postprandial glycemia in type 2 diabetes. RESEARCH
DESIGN AND METHODS Eight type 2 diabetic patients ingested 350 ml beef soup 30 min
before a potato meal; 55 g whey was added to either the soup (whey preload) or potato
(whey in meal) or no whey was given. RESULTS Gastric emptying was slowest after the
whey preload (P< 0.0005). The incremental area under the blood glucose curve was less …
OBJECTIVE
We evaluated whether a whey preload could slow gastric emptying, stimulate incretin hormones, and attenuate postprandial glycemia in type 2 diabetes.
RESEARCH DESIGN AND METHODS
Eight type 2 diabetic patients ingested 350 ml beef soup 30 min before a potato meal; 55 g whey was added to either the soup (whey preload) or potato (whey in meal) or no whey was given.
RESULTS
Gastric emptying was slowest after the whey preload (P < 0.0005). The incremental area under the blood glucose curve was less after the whey preload and whey in meal than after no whey (P < 0.005). Plasma glucose-dependent insulinotropic polypeptide, insulin, and cholecystokinin concentrations were higher on both whey days than after no whey, whereas glucagon-like peptide 1 was greatest after the whey preload (P < 0.05).
CONCLUSIONS
Whey protein consumed before a carbohydrate meal can stimulate insulin and incretin hormone secretion and slow gastric emptying, leading to marked reduction in postprandial glycemia in type 2 diabetes.
Am Diabetes Assoc
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