[HTML][HTML] Effects of all‐trans retinoic acid or chemotherapy on the molecular regulation of systemic blood coagulation and fibrinolysis in patients with acute …

MS Tallman, P Lefebvre, RM Baine, M Shoji… - Journal of Thrombosis …, 2004 - Elsevier
We studied the pathogenesis of the bleeding disorder in acute promyelocytic leukemia by
measuring procoagulant, profibrinolytic, and proinflammatory mediators in peripheral blood
and bone marrow cells from 25 previously untreated patients. Patients were induced with
either all‐trans retinoic acid (ATRA) or chemotherapy. Plasma levels of fibrinopeptide A
(FPA), fibrin d‐dimer, thrombin antithrombin (TAT) complex, prothrombin fragment 1.2 (F1.
2), urokinase‐type plasminogen activator (uPA), tissue‐type plasminogen activator (t‐PA) …
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