Effects of enzyme-based removal of collagen and elastin constituents on the biaxial mechanical responses of porcine atrioventricular heart valve anterior leaflets
The leaflets of the atrioventricular heart valves (AHVs) regulate the one-directional flow of
blood through a coordination of the extracellular matrix components, including the collagen
fibers, elastin, and glycosaminoglycans. Dysfunction of the AHVs, such as those caused by
unfavorable microstructural remodeling, lead to valvular heart diseases and improper blood
flow, which can ultimately cause heart failure. In order to better understand the mechanics
and remodeling of the AHV leaflets and how therapeutics can inadvertently cause adverse …
blood through a coordination of the extracellular matrix components, including the collagen
fibers, elastin, and glycosaminoglycans. Dysfunction of the AHVs, such as those caused by
unfavorable microstructural remodeling, lead to valvular heart diseases and improper blood
flow, which can ultimately cause heart failure. In order to better understand the mechanics
and remodeling of the AHV leaflets and how therapeutics can inadvertently cause adverse …
Effects of Enzyme-Based Removal of Collagen and Elastin Constituents on the Biaxial Mechanical Responses of Porcine Atrioventricular Heart Valve Anterior Leaflets
GA Duginski, CJ Ross, CH Johns, AL Echols… - papers.ssrn.com
The leaflets of the atrioventricular heart valves (AHVs) regulate the one-directional flow of
blood through a subtle coordination of the tissue's extracellular matrix (ECM) components,
including collagen fibers, elastin fibers, and glycosaminoglycans. Dysfunction of the AHVs,
such as those caused by unfavorable microstructural remodeling, results in valvular heart
diseases and improper blood flow that can eventually lead to heart failure. To better
understand mechanics and remodeling of the AHV leaflets and how therapeutics may …
blood through a subtle coordination of the tissue's extracellular matrix (ECM) components,
including collagen fibers, elastin fibers, and glycosaminoglycans. Dysfunction of the AHVs,
such as those caused by unfavorable microstructural remodeling, results in valvular heart
diseases and improper blood flow that can eventually lead to heart failure. To better
understand mechanics and remodeling of the AHV leaflets and how therapeutics may …
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