Numerous studies have examined the association between pharmacogenetic effects and
the response to inhaled corticosteroids (ICS) in patients with asthma. In fact, several single
nucleotide polymorphisms of a number of candidate genes have been identified that might
influence the clinical response to ICS in children with asthma. Their direct or indirect effects
depend on their role in the inflammatory process in asthma or the anti-inflammatory action of
corticosteroids, respectively. Among the genes identified, variants in T-box 21 (TBX21) and …

Numerous studies have studied the Association between pharmacogenetic eff ects and
response to inhaled glucocorticosteroids (ICS) in patients with asthma. In fact, several single
nucleotide polymorphisms of a number of candidate genes have been identifi ed that may aff
ect the clinical response to ICS in children with atopic asthma (BA). The results obtained to
date indicate various potential genetic factors associated with the reaction to IGCs, which
can be used to predict the individual therapeutic response of children with atopic asthma to …