Background Tranexamic acid reduces surgical bleeding and decreases mortality in patients
with traumatic extracranial bleeding. Intracranial bleeding is common after traumatic brain
injury (TBI) and can cause brain herniation and death. We aimed to assess the effects of
tranexamic acid in patients with TBI. Methods This randomised, placebo-controlled trial was
done in 175 hospitals in 29 countries. Adults with TBI who were within 3 h of injury, had a
Glasgow Coma Scale (GCS) score of 12 or lower or any intracranial bleeding on CT scan …

Comment: This study provides some good evidence for the use of DDAVP in AA-ICH,
considering the decrease in ICH expansion. Where this study is lacking, however, is
regarding clinical outcomes. Although increasing ICH volume has been shown to be
associated with poorer functional outcomes, DDAVP use was not shown to have a
significant impact on functional outcomes making further research necessary., EFFECTS OF
TRANEXAMIC ACID ON DEATH, DISABILITY, VASCULAR OCCLUSIVE EVENTS AND …