Efficient uptake and retention of iron oxide-based nanoparticles in HeLa cells leads to an effective intracellular delivery of doxorubicin
RC Popescu, D Savu, I Dorobantu, BS Vasile… - Scientific reports, 2020 - nature.com
The purpose of this study was to construct and characterize iron oxide nanoparticles
(IONPCO) for intracellular delivery of the anthracycline doxorubicin (DOX; IONPDOX) in
order to induce tumor cell inactivation. More than 80% of the loaded drug was released from
IONPDOX within 24 h (100% at 70 h). Efficient internalization of IONPDOX and IONPCO in
HeLa cells occurred through pino-and endocytosis, with both IONP accumulating in a
perinuclear pattern. IONPCO were biocompatible with maximum 27.9%±6.1% reduction in …
(IONPCO) for intracellular delivery of the anthracycline doxorubicin (DOX; IONPDOX) in
order to induce tumor cell inactivation. More than 80% of the loaded drug was released from
IONPDOX within 24 h (100% at 70 h). Efficient internalization of IONPDOX and IONPCO in
HeLa cells occurred through pino-and endocytosis, with both IONP accumulating in a
perinuclear pattern. IONPCO were biocompatible with maximum 27.9%±6.1% reduction in …
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