Eflornithine (DFMO) prevents progression of pancreatic cancer by modulating ornithine decarboxylase signaling
A Mohammed, NB Janakiram, V Madka… - Cancer Prevention …, 2014 - AACR
Ornithine decarboxylase (ODC) is the key rate-limiting enzyme in the polyamine synthesis
pathway and it is overexpressed in a variety of cancers. We found that polyamine synthesis
and modulation of ODC signaling occurs at early stages of pancreatic precursor lesions and
increases as the tumor progresses in Kras-activated p48Cre/+-LSL-KrasG12D/+ mice.
Interest in use of the ODC inhibitor eflornithine (DFMO) as a cancer chemopreventive agent
has increased in recent years since ODC was shown to be transactivated by the c-myc …
pathway and it is overexpressed in a variety of cancers. We found that polyamine synthesis
and modulation of ODC signaling occurs at early stages of pancreatic precursor lesions and
increases as the tumor progresses in Kras-activated p48Cre/+-LSL-KrasG12D/+ mice.
Interest in use of the ODC inhibitor eflornithine (DFMO) as a cancer chemopreventive agent
has increased in recent years since ODC was shown to be transactivated by the c-myc …
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