Ehrlich ascites tumour unbalances splenic cell populations and reduces responsiveness of T cells to Staphylococcus aureus enterotoxin B stimulation
Tumours must avoid host immune response to survive and proliferate; to achieve this
purpose, tumours interact with cells of the immune system by means of tumour secreted
factors. The alterations of splenic cell populations in mice bearing the Ehrlich ascites tumour
have been studied. A rapid and acute response was observed, characterized by a decrease
in both CD4 and CD8 T cells, and a transient increase in the number of B cells, which
peaked 2 days after tumour inoculation. An increase in macrophage population and in the …
purpose, tumours interact with cells of the immune system by means of tumour secreted
factors. The alterations of splenic cell populations in mice bearing the Ehrlich ascites tumour
have been studied. A rapid and acute response was observed, characterized by a decrease
in both CD4 and CD8 T cells, and a transient increase in the number of B cells, which
peaked 2 days after tumour inoculation. An increase in macrophage population and in the …
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