Background Myocarditis is a highly morbid complication of immune checkpoint inhibitor (ICI)
use that remains inadequately characterized. The QRS duration and the QTc interval are
standardized electrocardiographic measures that are prolonged in other cardiac conditions;
however, there are no data on their utility in ICI myocarditis. Methods From an international
registry, ECG parameters were compared between 140 myocarditis cases and 179 controls
across multiple time points (pre-ICI, on ICI prior to myocarditis, and at the time of …

Immune checkpoint inhibitors (ICIs) are associated with immune-related adverse events
including myocarditis, whilst improving cancer-related outcomes. There is thus a clinical
need to identify electrocardiographic manifestations of ICI-related myocarditis to guide
clinical management. PubMed was searched for clinical studies and case reports describing
electrocardiographic changes in patients with ICI-related myocarditis. A total of 6 clinical
studies and 79 case reports were included. This revealed a range of presentations for …