Emergence of resistance to daptomycin in a cohort of patients with methicillin-resistant Staphylococcus aureus persistent bacteraemia treated with daptomycin
O Gasch, M Camoez, MA Domínguez… - Journal of …, 2014 - academic.oup.com
O Gasch, M Camoez, MA Domínguez, B Padilla, V Pintado, B Almirante, C Martín…
Journal of Antimicrobial Chemotherapy, 2014•academic.oup.com… We aimed to ascertain the clinical impact of susceptibility loss during daptomycin therapy in
a cohort of patients with MRSA bacteraemia diagnosed and treated at 21 Spanish hospitals
from June 2008 to December 2009. An infectious disease specialist prospectively followed the
adult … Among 579 episodes of MRSA bacteraemia included in our study, daptomycin was
used as initial therapy in 44/518 (8%) patients, while 124/518 (24%) patients received the
antibiotic as definitive therapy: 77 (65%) at 6 mg/kg and 41 (35%) at higher doses (NB - in 6 …
a cohort of patients with MRSA bacteraemia diagnosed and treated at 21 Spanish hospitals
from June 2008 to December 2009. An infectious disease specialist prospectively followed the
adult … Among 579 episodes of MRSA bacteraemia included in our study, daptomycin was
used as initial therapy in 44/518 (8%) patients, while 124/518 (24%) patients received the
antibiotic as definitive therapy: 77 (65%) at 6 mg/kg and 41 (35%) at higher doses (NB - in 6 …
* Corresponding author. Infectious Diseases Service, Hospital de Bellvitge, Barcelona, Spain. Tel:+ 34-932607500; Fax:+ 34-932607637; E-mail: ogasch@ bellvitgehospital. cat† Members are listed in the Acknowledgements section.
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