Emerging role of non-coding RNAs in response of cancer cells to radiotherapy

K Ebahimzadeh, H Shoorei, SA Mousavinejad… - … -Research and Practice, 2021 - Elsevier
Radiotherapy is an effective method for treatment of a large proportion of human cancers.
Yet, the efficacy of this method is precluded by the induction of radioresistance in tumor cells
and the radiation-associated injury of normal cells surrounding the field of radiation. These
restrictions necessitate the introduction of modalities for either radiosensitization of cancer
cells or protection of normal cells against adverse effects of radiation. Non-coding RNAs
(ncRNAs) have essential roles in the determination of radiosensitivity. Moreover, ncRNAs …
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