Enantioselective titanium (III)-catalyzed reductive cyclization of ketonitriles.
J Streuff, M Feurer, P Bichovski, G Frey… - … (International ed. in …, 2012 - europepmc.org
J Streuff, M Feurer, P Bichovski, G Frey, U Gellrich
Angewandte Chemie (International ed. in English), 2012•europepmc.orgReduction, please! The title reaction affords α-hydroxyketones, a common structural motif in
biologically active natural products, in good yields and high enantioselectivities at room
temperature. The commercially available ansa-titanocene 1 was found to be an efficient
catalyst for this process, which presumably proceeds by addition of a ketyl radical to a nitrile.
biologically active natural products, in good yields and high enantioselectivities at room
temperature. The commercially available ansa-titanocene 1 was found to be an efficient
catalyst for this process, which presumably proceeds by addition of a ketyl radical to a nitrile.
Reduction, please! The title reaction affords α-hydroxyketones, a common structural motif in biologically active natural products, in good yields and high enantioselectivities at room temperature. The commercially available ansa-titanocene 1 was found to be an efficient catalyst for this process, which presumably proceeds by addition of a ketyl radical to a nitrile.
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