Endogenous β‐Carbolines as Clonidine‐Displacing Substances
ESJ Robinson, NJ Anderson, J Crosby… - Annals of the New …, 2003 - Wiley Online Library
ESJ Robinson, NJ Anderson, J Crosby, DJ Nutt, AL Hudson
Annals of the New York Academy of Sciences, 2003•Wiley Online LibraryEndogenous β‐carbolines, such as harmane, are known to occur in mammalian species
including humans. Radioligand binding studies have revealed that certain β‐carbolines
display high affinity for both I1 and I2 imidazoline‐binding sites (IBS). Functional studies
have shown that the β‐carboline harmane elicits many characteristics expected of an
endogenous ligand IBS. This article discusses the evidence relating to β‐carbolines as
endogenous ligands and presents a case for harmane and related compounds as …
including humans. Radioligand binding studies have revealed that certain β‐carbolines
display high affinity for both I1 and I2 imidazoline‐binding sites (IBS). Functional studies
have shown that the β‐carboline harmane elicits many characteristics expected of an
endogenous ligand IBS. This article discusses the evidence relating to β‐carbolines as
endogenous ligands and presents a case for harmane and related compounds as …
Abstract: Endogenous β‐carbolines, such as harmane, are known to occur in mammalian species including humans. Radioligand binding studies have revealed that certain β‐carbolines display high affinity for both I1 and I2 imidazoline‐binding sites (IBS). Functional studies have shown that the β‐carboline harmane elicits many characteristics expected of an endogenous ligand IBS. This article discusses the evidence relating to β‐carbolines as endogenous ligands and presents a case for harmane and related compounds as endogenous ligands for IBS.
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