Here, we report that Fe ions delivered into human mesenchymal stem cells (hMSCs) by
bioreducible metal nanoparticles (NPs) enhance their angiogenic and cell-homing efficacy
by controlling ion-triggered intracellular reactive oxygen species (ROS) and improve cell
migration, while reducing cytotoxicity. Endosome-triggered iron-ion-releasing nanoparticles
(ETIN) were designed to be low-pH responsive to take advantage of the low-pH conditions
(4–5) of endosomes for in situ iron-ion release. Due to the different redox potentials of Fe …

Heme Oxygenase 1-targeted Drug Delivery Systems for Acute Myeloid Leukemia Therapy
Seok-Beom Yong, Jaehyun Kim, Yong-Hee Kim1,† Department of Bioengineering, Hanyang
University; 1Department of Bioengineering, Hanyang University/Institute for Bioengineering
and Biopharmaceutical Research, Hanyang University Acute myeloid leukemia (AML) is
hematological malignancies with high mortality, and chemotherapy and bone marrow
transplantation are available, and recently challenged with immunotherapy. Heme …