In vivo EPR was used to investigate liver oxygenation in a hemodynamic model of septic
shock in mice. Oxygen-sensitive material was introduced either (i) as a slurry of fine particles
which localized at the liver sinusoids (pO2= 44.39±5.13 mmHg) or (ii) as larger particles
implanted directly into liver tissue to measure average pO2 across the lobule (pO2=
4.56±1.28 mmHg). Endotoxin caused decreases in pO2 at both sites early (5–15 min) and at
late time points (6 h after endotoxin; sinusoid= 11.22±2.48 mmHg; lobule= 1.16±0.42 …