Enhanced glycolysis and HIF-1α activation in adipose tissue macrophages sustains local and systemic interleukin-1β production in obesity
During obesity, macrophages infiltrate the visceral adipose tissue and promote inflammation
that contributes to type II diabetes. Evidence suggests that the rewiring of cellular
metabolism can regulate macrophage function. However, the metabolic programs that
characterize adipose tissue macrophages (ATM) in obesity are poorly defined. Here, we
demonstrate that ATM from obese mice exhibit metabolic profiles characterized by elevated
glycolysis and oxidative phosphorylation, distinct from ATM from lean mice. Increased …
that contributes to type II diabetes. Evidence suggests that the rewiring of cellular
metabolism can regulate macrophage function. However, the metabolic programs that
characterize adipose tissue macrophages (ATM) in obesity are poorly defined. Here, we
demonstrate that ATM from obese mice exhibit metabolic profiles characterized by elevated
glycolysis and oxidative phosphorylation, distinct from ATM from lean mice. Increased …
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