Enhanced survival of spiral ganglion cells after cessation of treatment with brain-derived neurotrophic factor in deafened guinea pigs
MJH Agterberg, H Versnel, LM van Dijk… - Journal of the …, 2009 - Springer
Exogenous delivery of neurotrophic factors into the cochlea of deafened animals rescues
spiral ganglion cells (SGCs) from degeneration. To be clinically relevant for human cochlear
implant candidates, the protective effect of neurotrophins should persist after cessation of
treatment and the treated SGCs should remain functional. In this study, the survival and
functionality of SGCs were investigated after temporary treatment with brain-derived
neurotrophic factor (BDNF). Guinea pigs in the experimental group were deafened, and 2 …
spiral ganglion cells (SGCs) from degeneration. To be clinically relevant for human cochlear
implant candidates, the protective effect of neurotrophins should persist after cessation of
treatment and the treated SGCs should remain functional. In this study, the survival and
functionality of SGCs were investigated after temporary treatment with brain-derived
neurotrophic factor (BDNF). Guinea pigs in the experimental group were deafened, and 2 …
[PDF][PDF] Enhanced Survival of Spiral Ganglion Cells After Cessation of Treatment with Brain-Derived Neurotrophic Factor in Deafened Guinea Pigs
SFL KLIS - academia.edu
Exogenous delivery of neurotrophic factors into the cochlea of deafened animals rescues
spiral ganglion cells (SGCs) from degeneration. To be clinically relevant for human cochlear
implant candidates, the protective effect of neurotrophins should persist after cessation of
treatment and the treated SGCs should remain functional. In this study, the survival and
functionality of SGCs were investigated after temporary treatment with brain-derived
neurotrophic factor (BDNF). Guinea pigs in the experimental group were deafened, and 2 …
spiral ganglion cells (SGCs) from degeneration. To be clinically relevant for human cochlear
implant candidates, the protective effect of neurotrophins should persist after cessation of
treatment and the treated SGCs should remain functional. In this study, the survival and
functionality of SGCs were investigated after temporary treatment with brain-derived
neurotrophic factor (BDNF). Guinea pigs in the experimental group were deafened, and 2 …
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