Two-photon excited photodynamic therapy (TPE-PDT) offers promising perspective for
cancer treatment [1] thanks to the deep penetration of the two-photon light in the
nearinfrared region and the unique spatial resolution it provides. In particular, the use of two-
photon excitable nanoparticles (NPs) for cancer diagnosis and therapy would offer new
opportunities in nanomedicine. TPE-PDT combined with NPs is indeed a new area of
investigation which is still in its infancy.[2, 3] In most of the studies, either a porphyrin or a …

Methods. 1H and 13C NMR spectra were recorded with a Bruker AC 400 spectrometer.
Chemical shifts (in δ units, ppm) are referenced to TMS using CHCl3 (δ= 7.26 ppm) and
CDCl3 (δ= 77.0 ppm) as the internal standards, respectively, for 1H and 13C NMR spectra.
IR spectra were recorded on a Perkin-Elmer 100 FT spectrophotometer. Absorption spectra
were recorded on a Hewlett-Packard 8453 spectrophotometer and fluorescence data were
collected on a Perkin-Elmer LS55 fluorimeter. Mass spectrometry was carried out at the …