Enhancement of the antimycobacterial activity of macrophages by ajoene
Ajoene, a garlic-derived sulfur-containing compound, has broad-spectrum antimicrobial
activity. To assess the potential of ajoene for treating tuberculosis (TB), we determined
whether it induces the stress response of the endoplasmic reticulum (ER), which plays an
important role in TB. We showed that ajoene stimulation induced the production of ER stress
sensor molecules and reactive oxygen species (ROS) levels. Ajoene-induced ROS
production was dependent on c-Jun N-terminal kinase (JNK) activation. Interestingly, the …
activity. To assess the potential of ajoene for treating tuberculosis (TB), we determined
whether it induces the stress response of the endoplasmic reticulum (ER), which plays an
important role in TB. We showed that ajoene stimulation induced the production of ER stress
sensor molecules and reactive oxygen species (ROS) levels. Ajoene-induced ROS
production was dependent on c-Jun N-terminal kinase (JNK) activation. Interestingly, the …
Enhancement of the antimycobacterial activity of macrophages by ajoene.
CJA Choi JiAe, CSN Cho SooNa, LYJ Lim YunJi… - 2018 - cabidigitallibrary.org
Ajoene, a garlic-derived sulfur-containing compound, has broad-spectrum antimicrobial
activity. To assess the potential of ajoene for treating tuberculosis (TB), we determined
whether it induces the stress response of the endoplasmic reticulum (ER), which plays an
important role in TB. We showed that ajoene stimulation induced the production of ER stress
sensor molecules and reactive oxygen species (ROS) levels. Ajoene-induced ROS
production was dependent on c-Jun N-terminal kinase (JNK) activation. Interestingly, the …
activity. To assess the potential of ajoene for treating tuberculosis (TB), we determined
whether it induces the stress response of the endoplasmic reticulum (ER), which plays an
important role in TB. We showed that ajoene stimulation induced the production of ER stress
sensor molecules and reactive oxygen species (ROS) levels. Ajoene-induced ROS
production was dependent on c-Jun N-terminal kinase (JNK) activation. Interestingly, the …
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