Objective To analyze the incidence and mortality trends of gastric cancer from 2000 to 2019 in China. Methods The descriptive epidemiologic method was conducted. Based on the Global Burden of Disease data from Institute for Health Metrics and Evaluation, the incidence rates, mortality rates, age-standardized incidence rates, age-standardized mortality rates of gastric cancer from 2000 to 2019 in China were collected. Observation indicators: (1) the incidence and mortality of gastric cancer in 2019 in China; (2) the age-standardized incidence and mortality of gastric cancer in 2019 in China; (3) the incidence trend of gastric cancer from 2000 to 2019 in China; (4) the mortality trend of gastric cancer from 2000 to 2019 in China. Count data were represented as absolute numbers, percentages with fractions. The incidence and mortality rates of gastric cancer were standardized by world standard population composition of Global Burden of Disease. Joinpoint software was used to construct a log-linear model for analysis of the changing trends of incidence and mortality rates over time in gastric cancer. Results (1) The incidence and mortality of gastric cancer in 2019 in China: 612 821 gastric cancer cases occurred in China in 2019. The crude incidence rate was 43.1/100 000, and the age-standardized incidence rate was 30.6/100 000. There were 451 332 males, with the crude incidence rate of 62.3/100 000 and age-standardized incidence rate of 47.4/100 000. There were 161 489 females, with the crude incidence rate of 23.2/100 000 and age-standardized incidence rate of 15.8/100 000. The number of gastric cancer death was 421 539 in China in 2019, with the crude mortality rate of 29.6/100 000 and age-standardized mortality rate of 21.7/100 000. There were 298 514 males, with the crude mortality rate of 41.2/100 000 and agestandardized mortality rate of 33.1/100 000. There were 123 025 females, with the crude mortality rate of 17.6/100 000 and age-standardized mortality rate of 12.2/100 000, respectively. (2) The agestandardized incidence and mortality of gastric cancer in 2019 in China: the number of gastric cancer cases aged<40 years was 20 855 in China in 2019, of which there were 14 005 males and 6 850 females, accounting for 3.1% (14 005/451 332) and 4.2%(6 850/161 489), respectively. The number of gastric cancer cases aged 40-49 years was 45 903 in China in 2019, of which there were 34 659 males and 11 244 females, accounting for 7.7%(34 659/451 332) and 7.0%(11 244/161 489), respectively. The number of gastric cancer cases aged 50-59 years was 111 975 in China in 2019, of which there were 87 156 males and 24 819 females, accounting for 19.3%(87 156/451 332) and 15.4%(24 819/161 489), respectively. The number of gastric cancer cases aged 60 -69 years was 180 434 in China in 2019, of which there were 137 939 males and 42 495 females, accounting for 30.6%(137 939/451 332) and 26.3%(42 495/161 489), respectively. The number of gastric cancer cases aged 70-79 years was 172 541 in China in 2019, of which there were 126 345 males and 46 196 females, accounting for 28.0%(126 345/451 332) and 28.6%(46 196/161 489), respectively. The number of gastric cancer cases aged >80 years was 81 113 in China in 2019, of which there were 51 228 males and 29 885 females, accounting for 11.4%(51 228/451 332) and 18.5%(29 885/161 489), respectively. The number of gastric cancer death cases aged<40 years was 8 463 in China in 2019, of which there were 5 508 males and 2 955 females, accounting for 1.8%(5 508/298 514) and 2.4% (2 955/123 025), respectively. The number of gastric cancer …