Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci
EW Demerath, W Guan, ML Grove… - Human molecular …, 2015 - academic.oup.com
Obesity is an important component of the pathophysiology of chronic diseases. Identifying
epigenetic modifications associated with elevated adiposity, including DNA methylation
variation, may point to genomic pathways that are dysregulated in numerous conditions. The
Illumina 450K Bead Chip array was used to assay DNA methylation in leukocyte DNA
obtained from 2097 African American adults in the Atherosclerosis Risk in Communities
(ARIC) study. Mixed-effects regression models were used to test the association of …
epigenetic modifications associated with elevated adiposity, including DNA methylation
variation, may point to genomic pathways that are dysregulated in numerous conditions. The
Illumina 450K Bead Chip array was used to assay DNA methylation in leukocyte DNA
obtained from 2097 African American adults in the Atherosclerosis Risk in Communities
(ARIC) study. Mixed-effects regression models were used to test the association of …
[PDF][PDF] Epigenome-wide Association Study (EWAS) of BMI, BMI Change, and Waist Circumference in African American Adults Identifies Multiple Replicated Loci
ÅK Zhou, JK Sandling10, LA Li20, MR Irvin, D Zhi12… - 2015 - academia.edu
Background. Obesity is an important component of the pathophysiology of chronic diseases.
Identifying epigenetic modifications associated with elevated adiposity, including DNA
methylation variation, may point to genomic pathways that are dysregulated in numerous
conditions. Methods. The Illumina 450K Bead Chip array was used to assay DNA
methylation in leukocyte DNA obtained from 2,097 African American adults in the
Atherosclerosis Risk in Communities (ARIC) study. Mixed effects regression models were …
Identifying epigenetic modifications associated with elevated adiposity, including DNA
methylation variation, may point to genomic pathways that are dysregulated in numerous
conditions. Methods. The Illumina 450K Bead Chip array was used to assay DNA
methylation in leukocyte DNA obtained from 2,097 African American adults in the
Atherosclerosis Risk in Communities (ARIC) study. Mixed effects regression models were …
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