ErbB-directed immunotherapy: antibodies in current practice and promising new agents
E Friedländer, M Barok, J Szöllősi, G Vereb - Immunology letters, 2008 - Elsevier
The ErbB family is well known for its significance in oncogenesis. As bad prognostic
markers, overexpressed or mutated ErbB1 and ErbB2 have an important role in the
molecular diagnosis of various cancers, but as membrane proteins, expressed often
selectively in tumor tissues, they can be targeted with kinase inhibitors or therapeutic
antibodies. In addition to trastuzumab, the first humanized antibody that was approved for
the therapy of solid tumors by the FDA, now many humanized antibodies are in late clinical …
markers, overexpressed or mutated ErbB1 and ErbB2 have an important role in the
molecular diagnosis of various cancers, but as membrane proteins, expressed often
selectively in tumor tissues, they can be targeted with kinase inhibitors or therapeutic
antibodies. In addition to trastuzumab, the first humanized antibody that was approved for
the therapy of solid tumors by the FDA, now many humanized antibodies are in late clinical …
以上显示的是最相近的搜索结果。 查看全部搜索结果