Importance Individuals with chronic pain who use long-term opioid therapy (LTOT) are at risk
of opioid use disorder and other harmful outcomes. Rotation to buprenorphine may be
considered, but the outcomes of such rotation in this population have not been
systematically reviewed. Objective To synthesize the evidence on rotation to buprenorphine
from full μ-opioid receptor agonists among individuals with chronic pain who were receiving
LTOT, including the outcomes of precipitated opioid withdrawal, pain intensity, pain …