… Parkinson's disease is one of the most common neurodegenerative diseases. Animal
models have contributed a large part to our understanding and therapeutics developed for …

… Thus, the reserpine model is a good mimic of the disease biochemistry and an important
model of … Any product that may be evaluated in this article or claim that may be made by its …

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the
progressive loss of dopaminergic nigral neurons and striatal dopamine. Despite the advances …

… preclinical model used today for Parkinson's disease that take in consideration both preclinical
model … Any product that may be evaluated in this article or claim that may be made by its …

… many anti-parkinsonian compounds, such as levodopa, which was first evaluated in an
animal model and is the gold standard of parkinsonian treatment today. …

… pathophysiology and evaluate therapeutic strategies for the disease. The … models, their
applications, and methods of evaluation, with emphasis on the importance of matching the model …

… models for the evaluation of treatment strategies for Parkinson's disease, we conclude
that models have been successfully applied to evaluate pharmaceutical as well as surgical …

… Due to the high cost and ethical issues, NHP studies are often performed for preclinical
evaluation of therapies [14]. The parkinsonian symptoms in NHP are generated through …

… transgenic models that replicate most of the disease‐… PD models have their own specificities
and limitations, which must be carefully taken into consideration when choosing the model …

… After further evaluation, 4 publications became the primary focus of this review … modeling
outcome, an equation for the model, and model parameter values. Based on previous models …