Evolution of RND efflux pumps in the development of a successful pathogen
V Naidu, A Bartczak, AJ Brzoska, P Lewis… - Drug Resistance …, 2023 - Elsevier
Aims This study examined the origins and evolution of the AdeABC, AdeFGH and AdeIJK
efflux pumps in the Acinetobacter genus, including human and animal pathogens and
species from non-clinical environments. Methods Comparative genome analyses were
performed using the reference sequences for 70 Acinetobacter species to identify putative
orthologs of AdeABC, AdeFGH and AdeIJK and their regulators. Sequence similarities and
the genomic locations of coding sequences were correlated with phylogeny to infer modes …
efflux pumps in the Acinetobacter genus, including human and animal pathogens and
species from non-clinical environments. Methods Comparative genome analyses were
performed using the reference sequences for 70 Acinetobacter species to identify putative
orthologs of AdeABC, AdeFGH and AdeIJK and their regulators. Sequence similarities and
the genomic locations of coding sequences were correlated with phylogeny to infer modes …
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