Evolution of the Pseudomonas aeruginosa mutational resistome in an international Cystic Fibrosis clone
Emergence of epidemic clones and antibiotic resistance development compromises the
management of Pseudomonas aeruginosa cystic fibrosis (CF) chronic respiratory infections.
Whole genome sequencing (WGS) was used to decipher the phylogeny, interpatient
dissemination, WGS mutator genotypes (mutome) and resistome of a widespread clone
(CC274), in isolates from two highly-distant countries, Australia and Spain, covering an 18-
year period. The coexistence of two divergent CC274 clonal lineages was revealed, but …
management of Pseudomonas aeruginosa cystic fibrosis (CF) chronic respiratory infections.
Whole genome sequencing (WGS) was used to decipher the phylogeny, interpatient
dissemination, WGS mutator genotypes (mutome) and resistome of a widespread clone
(CC274), in isolates from two highly-distant countries, Australia and Spain, covering an 18-
year period. The coexistence of two divergent CC274 clonal lineages was revealed, but …
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