Importance Complex disorders, such as bipolar disorder (BD), likely result from the influence
of both common and rare susceptibility alleles. While common variation has been widely
studied, rare variant discovery has only recently become feasible with next-generation
sequencing. Objective To utilize a combined family-based and case-control approach to
exome sequencing in BD using multiplex families as an initial discovery strategy, followed
by association testing in a large case-control meta-analysis. Design, Setting, and …