Experimental models of corneal endothelial cell therapy and translational challenges to clinical practice
K Rolev, P Coussons, L King, M Rajan - Experimental Eye Research, 2019 - Elsevier
The human corneal endothelium (CE) is a post-mitotic monolayer of endothelial cells,
thought to be incapable of in vivo regeneration. Dysfunction of the CE is a commonly cited
indication for corneal transplantation, with corneal blindness being the fifth most common
cause of blindness globally. In 2012 alone 184,576 corneal transplants were performed in
116 countries (Gain et al., 2016). Presently, outcomes following human corneal
transplantation have been reported to have over 97% success rate in restoring the …
thought to be incapable of in vivo regeneration. Dysfunction of the CE is a commonly cited
indication for corneal transplantation, with corneal blindness being the fifth most common
cause of blindness globally. In 2012 alone 184,576 corneal transplants were performed in
116 countries (Gain et al., 2016). Presently, outcomes following human corneal
transplantation have been reported to have over 97% success rate in restoring the …
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