A 6 degrees-of-freedom (6DoF) sensor, measuring three components of translational acceleration and three components of rotation rate, provides the full history of motion it is exposed to. In Earth sciences 6DoF sensors have shown great potential in exploring the interior of our planet and its seismic sources. In space sciences, apart from navigation, 6DoF sensors are, up to now, only rarely used to answer scientific questions. As a first step of establishing 6DoF motion sensing deeper into space sciences, this article describes novel scientific approaches based on 6DoF motion sensing with substantial potential for constraining the interior structure of planetary objects and asteroids. Therefore we estimate 6DoF-signal levels that originate from lander–surface interactions during landing and touchdown, from a body’s rotational dynamics as well as from seismic ground motions. We discuss these signals for an exemplary set of target bodies including Dimorphos, Phobos, Europa, the Earth’s Moon and Mars and compare those to self-noise levels of state-of-the-art sensors.