Expression and activation of MAP kinases, ERK1/2, in the human villous trophoblasts

N Kita, J Mitsushita, S Ohira, Y Takagi, T Ashida… - Placenta, 2003 - Elsevier
Mitogen-activated protein kinase (MAP kinase) plays a central role in the signal transduction
for diverse cellular responses, such as proliferation, differentiation, stress response and cell
death, via activation after binding of growth factors to the respective receptors on the cell
membrane. In the human placental tissues, however, little is known about the expression
and activation of the classical MAP kinases, extracellular signal-regulated kinase1/2
(ERK1/2). We therefore examined the expression of ERK1/2 in the human chorionic and …
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