Expression of claudin-7 and-8 along the mouse nephron
WY Li, CL Huey, ASL Yu - American Journal of Physiology …, 2004 - journals.physiology.org
WY Li, CL Huey, ASL Yu
American Journal of Physiology-Renal Physiology, 2004•journals.physiology.orgClaudins are integral membrane proteins of the tight junction that determine the magnitude
and selectivity of paracellular permeability in epithelial tissues. The mammalian renal tubule
exhibits considerable heterogeneity in the permeability properties of its different segments.
To determine the nephron segment localization of claudin-7 and-8, immunofluorescence
staining of mouse kidney sections was performed using isoform-specific antibodies. Claudin-
8 was found to be expressed primarily at the tight junction along the entire aldosterone …
and selectivity of paracellular permeability in epithelial tissues. The mammalian renal tubule
exhibits considerable heterogeneity in the permeability properties of its different segments.
To determine the nephron segment localization of claudin-7 and-8, immunofluorescence
staining of mouse kidney sections was performed using isoform-specific antibodies. Claudin-
8 was found to be expressed primarily at the tight junction along the entire aldosterone …
Claudins are integral membrane proteins of the tight junction that determine the magnitude and selectivity of paracellular permeability in epithelial tissues. The mammalian renal tubule exhibits considerable heterogeneity in the permeability properties of its different segments. To determine the nephron segment localization of claudin-7 and -8, immunofluorescence staining of mouse kidney sections was performed using isoform-specific antibodies. Claudin-8 was found to be expressed primarily at the tight junction along the entire aldosterone-sensitive distal nephron and in the late segments of the thin descending limbs of long-looped nephrons. This pattern of expression is consistent with the putative role of claudin-8 as a paracellular cation barrier. By contrast, claudin-7 was found in the same nephron segments as claudin-8, but it was expressed primarily at the basolateral membrane.
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