Triton X-100 applications as surfactant raises concern on water and soil environment due to its non-biodegradability and inhibition effect. This paper aims at reviewing Triton X-100 biodegradability and inhibition literature. It shows Triton X-100 is biodegradable by aerobic and anaerobic municipal wastewater sludge and Vibrio cyclitrophicus-sp-Nov organism. Adsorption and biodegradation are mechanisms of Triton removal. Triton inhibits anaerobic sludge organisms and some single aerobic organisms. Inhibition mechanisms are substrate shortage, physiological membrane-damaging and/or alteration in organism cell membrane. Thus Triton X-100 fate in the environment and its sustainable application can be controlled via proper selection of organism type, Triton concentration, and substrate.