Feasibility of clinically practical ultra-high dose rate (FLASH) radiation delivery by a reversible configuration of a standard clinical-use linear accelerator
Purpose/Objective (s) Multiple preclinical in-vivo studies of ultra-high dose rate (FLASH)
radiation therapy (RT) have shown reduced normal tissue toxicity with equivalent tumor
control when compared to conventional dose rate RT, with benefits seen at dose rates≥ 40
Gray (Gy) per second. Leveraging these benefits for clinical translation could profoundly
impact RT. Extending an institutionally established reversible configuration of a linear
accelerator (LINAC) for FLASH, we explored the feasibility of LINAC-based FLASH RT for …
radiation therapy (RT) have shown reduced normal tissue toxicity with equivalent tumor
control when compared to conventional dose rate RT, with benefits seen at dose rates≥ 40
Gray (Gy) per second. Leveraging these benefits for clinical translation could profoundly
impact RT. Extending an institutionally established reversible configuration of a linear
accelerator (LINAC) for FLASH, we explored the feasibility of LINAC-based FLASH RT for …
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