Ferrocenyl hydroxytamoxifen: a prototype for a new range of oestradiol receptor site-directed cytotoxics
S Top, J Tang, A Vessières, D Carrez… - Chemical …, 1996 - pubs.rsc.org
Chemical Communications, 1996•pubs.rsc.org
… The synthesis of ferrocenyl hydroxytamoxifen 1, a prototype for a new range of oestradiol
receptor site-directed cytotoxic compounds, and some preliminary biochemical tests are
reported. … Given the fact that (2)-4-hydroxytamoxifen (OH-TAM), with its OH group
enhancing recognition of the oestradiol receptor, is the active metabolite of TAM, and the
fact that ferrocene's first metabolite is the femcinium ion, itself a proven antitumour agent,' a
synthetic method for (2)-Fc-OH-TAM 1 or related compounds would seem to be particularly …
receptor site-directed cytotoxic compounds, and some preliminary biochemical tests are
reported. … Given the fact that (2)-4-hydroxytamoxifen (OH-TAM), with its OH group
enhancing recognition of the oestradiol receptor, is the active metabolite of TAM, and the
fact that ferrocene's first metabolite is the femcinium ion, itself a proven antitumour agent,' a
synthetic method for (2)-Fc-OH-TAM 1 or related compounds would seem to be particularly …
The synthesis of ferrocenyl hydroxytamoxifen 1, a prototype for a new range hof oestradiol receptor site-directed cytotoxic compounds, and some preliminary biochemical tests are reported.
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