Symptoms of Parkinson's disease arise due to neuronal loss in multiple brain regions,
especially dopaminergic neurons in the substantia nigra pars compacta. Current therapies
aim to restore dopamine levels in the brain, but while these provide symptomatic benefit,
they do not prevent ongoing neurodegeneration. Preventing neuronal death is a major
strategy for disease-modifying therapies; however, while many pathogenic factors have
been identified, it is currently unknown how neurons die in the disease. Ferroptosis, a …