Fibroids and reproductive outcomes: a systematic literature review from conception to delivery
PC Klatsky, ND Tran, AB Caughey… - American journal of …, 2008 - Elsevier
We examined the published relationship between uterine fibroids and reproductive
outcomes. Submucosal fibroids had the strongest association with lower ongoing pregnancy
rates, odds ratio, 0.5; 95% confidence interval, 0.3-0.8, primarily through decreased
implantation. Cumulative pregnancy rates appeared slightly lower in patients with intramural
fibroids 36.9% vs 41.1%, which may reflect biases in the literature; however, patients with
intramural fibroids also experienced more miscarriages, 20.4% vs 12.9%. Adverse obstetric …
outcomes. Submucosal fibroids had the strongest association with lower ongoing pregnancy
rates, odds ratio, 0.5; 95% confidence interval, 0.3-0.8, primarily through decreased
implantation. Cumulative pregnancy rates appeared slightly lower in patients with intramural
fibroids 36.9% vs 41.1%, which may reflect biases in the literature; however, patients with
intramural fibroids also experienced more miscarriages, 20.4% vs 12.9%. Adverse obstetric …
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