First synthesis of antimalarial Machaeriols A and B
… Machaeriol B showed growth inhibition of the chloroquine-resistant P. falciparum W-2
clone (IC 50 =120 ng/mL; SI=>40); while Machaeriol A was found to be only weakly active.
They also reported that these compounds showed good antibacterial activity against
Staphylococcus aureus and methicillin-resistant S. aureus, with IC 50 values of 5 and 4.5 μg/mL,
respectively. … In summary, the first syntheses of Machaeriols A (1) and B (2) have been
accomplished efficiently from commercially available phloroglucinol and S-citronellal, giving …
clone (IC 50 =120 ng/mL; SI=>40); while Machaeriol A was found to be only weakly active.
They also reported that these compounds showed good antibacterial activity against
Staphylococcus aureus and methicillin-resistant S. aureus, with IC 50 values of 5 and 4.5 μg/mL,
respectively. … In summary, the first syntheses of Machaeriols A (1) and B (2) have been
accomplished efficiently from commercially available phloroglucinol and S-citronellal, giving …
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