Folic acid for the prevention of colorectal adenomas: a randomized clinical trial
ContextLaboratory and epidemiological data suggest that folic acid may have an
antineoplastic effect in the large intestine. ObjectiveTo assess the safety and efficacy of folic
acid supplementation for preventing colorectal adenomas. Design, Setting, and
ParticipantsA double-blind, placebo-controlled, 2-factor, phase 3, randomized clinical trial
conducted at 9 clinical centers between July 6, 1994, and October 1, 2004. Participants
included 1021 men and women with a recent history of colorectal adenomas and no …
antineoplastic effect in the large intestine. ObjectiveTo assess the safety and efficacy of folic
acid supplementation for preventing colorectal adenomas. Design, Setting, and
ParticipantsA double-blind, placebo-controlled, 2-factor, phase 3, randomized clinical trial
conducted at 9 clinical centers between July 6, 1994, and October 1, 2004. Participants
included 1021 men and women with a recent history of colorectal adenomas and no …
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