Frameworks for targeting RNA with small molecules

AU Juru, AE Hargrove - Journal of Biological Chemistry, 2021 - ASBMB
Since the characterization of mRNA in 1961, our understanding of the roles of RNA
molecules has significantly grown. Beyond serving as a link between DNA and proteins,
RNA molecules play direct effector roles by binding to various ligands, including proteins,
DNA, other RNAs, and metabolites. Through these interactions, RNAs mediate cellular
processes such as the regulation of gene transcription and the enhancement or inhibition of
protein activity. As a result, the misregulation of RNA molecules is often associated with …
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