Decreased expression of mitochondrial frataxin (FXN) causes Friedreich's ataxia (FRDA), a
neurodegenerative disease with type 2 diabetes (T2D) as severe comorbidity. Brown
adipose tissue (BAT) is a mitochondria-enriched and anti-diabetic tissue that turns excess
energy into heat to maintain metabolic homeostasis. Here we report that the FXN knock-
in/knock-out (KIKO) mouse shows hyperlipidemia, reduced energy expenditure and insulin
sensitivity, and elevated plasma leptin, recapitulating T2D-like signatures. FXN deficiency …

Correction: Frataxin deficiency induces lipid accumulation and affects thermogenesis in brown
adipose tissue - PMC … Correction: Frataxin deficiency induces lipid accumulation and affects
thermogenesis in brown adipose tissue … This corrects the article "Frataxin deficiency induces
lipid accumulation and affects thermogenesis in brown adipose tissue" in volume 11, 51. …