Free fatty acids rewire cancer metabolism in obesity-associated breast cancer via estrogen receptor and mTOR signaling
Z Madak-Erdogan, S Band, YC Zhao, BP Smith… - Cancer research, 2019 - AACR
Obesity is a risk factor for postmenopausal estrogen receptor alpha (ERα)-positive (ER+)
breast cancer. Molecular mechanisms underlying factors from plasma that contribute to this
risk and how these mechanisms affect ERα signaling have yet to be elucidated. To identify
such mechanisms, we performed whole metabolite and protein profiling in plasma samples
from women at high risk for breast cancer, which led us to focus on factors that were
differentially present in plasma of obese versus nonobese postmenopausal women. These …
breast cancer. Molecular mechanisms underlying factors from plasma that contribute to this
risk and how these mechanisms affect ERα signaling have yet to be elucidated. To identify
such mechanisms, we performed whole metabolite and protein profiling in plasma samples
from women at high risk for breast cancer, which led us to focus on factors that were
differentially present in plasma of obese versus nonobese postmenopausal women. These …
[PDF][PDF] Free fatty acids rewire cancer metabolism in obesity-associated breast cancer via estrogen receptor and mTOR signaling
MP Johnson, N Marino, AMV Storniolo, A Jodi - academia.edu
Obesity is a risk factor for postmenopausal estrogen receptor alpha (ERα) positive (ER (+))
breast cancer. Molecular mechanisms underlying factors from plasma that contribute to this
risk and how these mechanisms affect ERα signaling have yet to be elucidated. To identify
such mechanisms, we performed whole metabolite and protein profiling in plasma samples
from women at high risk for breast cancer, which led us to focus on factors that were
differentially present in plasma of obese vs. non-obese postmenopausal women. These …
breast cancer. Molecular mechanisms underlying factors from plasma that contribute to this
risk and how these mechanisms affect ERα signaling have yet to be elucidated. To identify
such mechanisms, we performed whole metabolite and protein profiling in plasma samples
from women at high risk for breast cancer, which led us to focus on factors that were
differentially present in plasma of obese vs. non-obese postmenopausal women. These …
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