[HTML][HTML] Fulminant hepatitis due to very severe sinusoidal obstruction syndrome (SOS/VOD) after autologous peripheral stem cell transplantation: a case report
E Tavernier, E Chalayer, J Cornillon, A Pouvaret… - BMC Research …, 2018 - Springer
E Tavernier, E Chalayer, J Cornillon, A Pouvaret, JA Martignoles, F Casteillo, J Terreaux…
BMC Research Notes, 2018•SpringerBackground Hepatic veno-occlusive disease, also called sinusoidal obstruction syndrome
(SOS/VOD), is a potentially fatal complication of allogeneic or autologous hematopoietic
stem cell transplantation. A plethora of transplant and patient-related risk factors predispose
to SOS/VOD and should be taken into account for prognosis assessment as well as for
adequate therapeutic intervention. Case presentation We describe the case of a mantle cell
lymphoma patient who developed a fulminant hepatitis following oxaliplatin-containing …
(SOS/VOD), is a potentially fatal complication of allogeneic or autologous hematopoietic
stem cell transplantation. A plethora of transplant and patient-related risk factors predispose
to SOS/VOD and should be taken into account for prognosis assessment as well as for
adequate therapeutic intervention. Case presentation We describe the case of a mantle cell
lymphoma patient who developed a fulminant hepatitis following oxaliplatin-containing …
Background
Hepatic veno-occlusive disease, also called sinusoidal obstruction syndrome (SOS/VOD), is a potentially fatal complication of allogeneic or autologous hematopoietic stem cell transplantation. A plethora of transplant and patient-related risk factors predispose to SOS/VOD and should be taken into account for prognosis assessment as well as for adequate therapeutic intervention.
Case presentation
We describe the case of a mantle cell lymphoma patient who developed a fulminant hepatitis following oxaliplatin-containing intensive chemotherapy and autologous transplantation. This clinical manifestation was secondary to a very severe SOS/VOD. The patient did not exhibit the usual risk factors and presented a non-classical form with major cytolysis, thus puzzling SOS/VOD diagnosis in this context.
Conclusion
SOS has been previously reported after oxaliplatin-based chemotherapy regimens for colorectal cancers, in particular in patients with colorectal liver metastases. We therefore suspected a potential relationship with oxaliplatin-based regimen as a driver of SOS/VOD in a non-susceptible lymphoma patient. With regards to this case, clinicians and especially intensivists should be aware of this atypical presentation.
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