The cytoskeleton is a dynamic network of filamentous protein polymers required for virtually
all cellular processes. It consists of three major classes, filamentous actin (F-actin),
intermediate filaments, and microtubules, all displaying characteristic structural properties,
functions, cellular distributions, and sets of interacting regulatory proteins. One unique class
of proteins, the spectraplakins, bind, regulate, and integrate the functions of all three classes
of cytoskeleton proteins. Spectraplakins are giant, evolutionary conserved multidomain …